Single IRB (SIRB) Review

The basis for the Single IRB Model is to allow multiple institutions that are conducting the same protocol to use a single IRB for review, instead of using multiple IRBs to review the research at the sites individually.  The Single IRB Model has been in use for many years, across a wide variety of studies and circumstances.

At the University of Utah, we feel that while Single IRB Review may help to streamline the study initiation process, it is important to understand all of the components of the Single IRB model that must be completed beyond just the IRB review.  Efficient performance of all stages of study initiation and conduct will help to ensure multi-site research is effective and expeditious. 

See also: Conducting Research with External Institutions

Getting Started

SIRB Learning Videos

Watch videos to help you learn more about how the SIRB model works. 

reliance consultation request

Submit this online form if...

  • You would like the UUIRB to be the SIRB for your study
  • You would like the UUIRB to defer review to another IRB



See the resources the UUIRB has in order to be your SIRB.



Your Role & Our CIRB and HRPP Services

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Quick Links: Resources

block u  Reliance Consultation Request    tinlogo Trial Innovation Network
block u  ERICA Access Instructions   smartlogo  SMART IRB
block u  Local Review Report Form comingsoon   exchange  IRB Reliance Exchange
block u  Local Context Submission Form comingsoon    
block u  Site-Specific Local Context Database    


Last Updated: 1/17/19